Isoniazid toxicity Writing Paper Essay

Isoniazid toxicity Writing Paper

Overview
Certain drugs used primarily in human medicine can be used under certain circumstances in animals. However, there are some that must be used with caution or not at all in an animal due to their toxicity profile. The following project is intended for you to investigate the effects of a specific human drug that is toxic in dogs. Explore the drug mechanism and dog physiology factors that contribute to toxicity, and the treatment approach to toxicosis. This project relates to the material you have learned regarding pharmacology (and toxicology) principals, recognition of drug-related clinical signs, and appropriate approaches to these.

Instructions
You work in a veterinary hospital where a few clients have presented dogs with illnesses after they were given or accidentally ingested isoniazid tablets that belonged to clients taking these tablets for their own tuberculosis infections. In most cases, a dog had clinical signs after ingesting one or more 300 mg isoniazid tablets, one of these cases proved fatal. The hospital is collaborating with other veterinary clinics and hospitals that have reported similar cases of isoniazid overdoses in dogs.

Students are required to write a research paper discussing isoniazid overdose in dogs. The paper must address the five components listed below.

Explain the mechanism of isoniazid’s antimicrobial action and how this relates to toxicity in dogs
Discuss the unique dog biochemistry that promotes isoniazid toxicity in dogs
Identify the organ systems affected by isoniazid toxicity in dogs and describe clinical signs associated with the effects on these organ systems
Describe the primary treatment approach to isoniazid toxicity and the antidote for isoniazid toxicosis.
Explain the mechanism of action of the antidote used when treating isoniazid toxicity
Project Specifications
You must turn in a single word-processing document, 3-6 pages in length, using Times New Roman font, double spaced with normal 1” margins
The title page should contain the following information:
The Title: Vet 305 Advanced Veterinary Pharmacology
Your Name
Your student ID number
The lesson number
Your email address
The date the project was submitted
The paper must address the five required components.
The paper should be easy to read with correct spelling, grammar, and punctuation.
The paper should include a minimum of four references listed in APA format at the end of the document on a works cited page. You can use the course textbook as one reference, but you’ll need at least three other outside references. Sources used should be from medical publications or websites. Do not use sites like Wikipedia.
Summary
Explore the drug mechanism and dog physiology factors that contribute to toxicity, clinical signs of toxicity, and the treatment approach to isoniazid toxicosis.

Grading Criteria
The following rubric will be used to grade your project:

The highest total score possible is 100.

Components	15-11 Points	10-6 Points	5-0 Points
Explain the mechanism of isoniazid’s antimicrobial action and how this relates to toxicity in dogs	Provides accurate information and numerous details about mechanism of isoniazid’s antimicrobial action and how this relates to toxicity in dogs	Provides mostly accurate information and a few details about mechanism of isoniazid’s antimicrobial action and how this relates to toxicity in dogs	Provides little to no accurate information and little to no detail about mechanism of isoniazid’s antimicrobial action and how this relates to toxicity in dogs
Discuss the unique dog biochemistry that promotes isoniazid toxicity in dogs	Provides accurate information and numerous details about the unique dog biochemistry that promotes isoniazid toxicity in dogs	Provides mostly accurate information and a few details about the unique dog biochemistry that promotes isoniazid toxicity in dogs	Provides little to no accurate information and little to no detail about the unique dog biochemistry that promotes isoniazid toxicity in dogs
Identify the organ systems affected by isoniazid toxicity in dogs and describe clinical signs associated with the effects on these organ systems	Provides accurate information and numerous details about the organ systems affected and clinical signs.	Provides mostly accurate information and a few details about the organ systems affected and clinical signs.	Provides little to no accurate information and little to no detail about the organ systems affected and clinical signs
Describe the primary treatment approach to isoniazid toxicity and the antidote for isoniazid toxicosis	Provides accurate information and numerous details about the primary treatment approach to isoniazid toxicity and the antidote for isoniazid toxicosis.	Provides mostly accurate information and a few details about primary treatment approach to isoniazid toxicity and the antidote for isoniazid toxicosis.	Provides little to no accurate information and little to no detail about primary treatment approach to isoniazid toxicity and the antidote for isoniazid toxicosis.
Explain the mechanism of action of the antidote used when treating isoniazid toxicity	Provides accurate information and numerous details about the mechanism of action of the antidote used when treating isoniazid toxicity	Provides mostly accurate information and a few details about mechanism of action of the antidote used when treating isoniazid toxicity	Provides little to no accurate information and little to no detail about mechanism of action of the antidote used when treating isoniazid toxicity
Grammar, spelling, punctuation	Little to no grammar, spelling or punctuation errors	Minor grammar, spelling or punctuation errors	Many grammar, spelling or punctuation errors
References	10 Points	9-6 Points	5-0 Points
References in APA Format	Provides a minimum of four references in correct APA format.	Provides 2 or 3 required references with minimal APA format errors	Provides 1 to 2 required references but not in APA format or no references are included

Isoniazid toxicity Writing Paper Essay

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